An experimental coronavirus vaccine made by Moderna provoked promising immune responses and appeared safe in the first 45 people who received it, researchers reported on Tuesday. Phase 3 tests involving 30,000 people are expected to begin on July 27.https://t.co/Qd7L7oSEjX pic.twitter.com/Clk9jJJFGo
— The New York Times (@nytimes) July 14, 2020
Please consider Moderna Phase 1 results show coronavirus vaccine safe, induces immune response.
The results released Tuesday involved three doses of the vaccine, tested in groups of 15 volunteers aged 18-55 who got two shots, 28 days apart. The groups tested 25, 100 or 250 micrograms of the vaccine.
Adverse events after the second dose occurred in seven of the 13 volunteers who got the 25-microgram dose, all 15 participants who received the 100 microgram dose and all 14 who got the 250 microgram dose. In the highest-dose group, three patients had severe reactions such as fever, chills, headache or nausea. One of these had a fever of 103.28 Fahrenheit (39.6 C).
“We didn’t see any events that are characterized as serious adverse events,” said lead author Dr Lisa Jackson of Kaiser Permanente Washington Health Research Institute in Seattle, referring to reactions that require hospitalization or result in death.
Moderna started has 2 tests in May. And will start Phase 3 tests with 30,000 volunteers on July 27.
Best Wishes.
Mish
Moderna Phase One Covid Test Deemed a Success
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Mish
From yesterday’s NYTimes, “Moderna, Johnson & Johnson and the Oxford-AstraZeneca group have received a total of $2.2 billion in federal funding to support their vaccine programs.”
Vaccines sound great but in reality they aren’t going to be anywhere near 100% effective. And since most on here probably don’t realize that the rationale of using widespread vaccination depends a good deal on herd immunity, which they also don’t believe in, we may be relying on hydroxychoroquine more. Oops, they don’t believe in that either, despite the recent studies.
The concept of “herd immunity” can be achieved naturally if surviving individuals acquire relatively long-lasting immunity OR by means of a vaccine that confers relatively long-lasting immunity … or a combination of the two.
But yes, the mechanism by which a vaccine confers immunity might or might not depend upon triggering an individual’s natural immune response the same way being infected by the actual virus would. If it does, and natural immunity is not long-lasting, then the immunity response produced by the vaccine won’t be long-lasting either. But some of the reports I’ve read suggest that a vaccine might work differently that that … we can only wait and see.
And BTW, I’ve been convinced for quite a while of the efficacy of HCQ+Zinc administered as early as possible after infection … and been very suspicious of the many studies seemingly “designed to fail” by administering late or omitting use of Zinc, etc. I think there has been a definite Pharma Profit Push that is responsible for that. Especially after the way Remdesivir was fast-tracked despite studies showing very little benefit at all.
If you knew your company had a good vaccine would you be selling shares in your company? link to secform4.com
LOL! NET SALES ~$273 MILLION … that’s a confident bunch!
Confident and rich. It certainly pays to hype phase 1 results that have yet to be approved.
Naaah, it’s called hedging your bets 😉
Increased antibodies might be harmful:
I have many friends who say they are afraid of taking a vaccine that was rushed to market and they would wait to see how it goes. I say, isn’t getting Covid worse? They say…. I may not get covid but if I get a shot then I know I will suffer the side effects that could be very bad. These are not anti vaxers. They all believe in vaccines in general. It’s bizarre but they think too many corners will be cut and any vaccine could be more dangerous than we know. I will be first in line for a vaccine but I wonder if I am the exception?
Historically, some vaccines have had problems when they first went into mass production. The polio vaccine is one famous example. Some of the early vaccine infected people with polio, apparently due to a manufacturing error. People remember that.
I have not seen anything stating the SARS-COV-2 vaccine will be a “live vaccine” like polio was, but they are deploying new technology. As I recall, at least one of the vaccines infects the person with a different engineered virus that triggers the body to produce SARS-COV-2 antibodies without causing illness. It’s new tech.
I can tell you that I am not going to be first in line for the vaccine. I am going to wait awhile; perhaps a long while. I would like to see how it goes for others.
EDIT: Speak of the devil… Bloomberg has a story out today about a vaccine that is considered the front-runner. University of Oxford candidate run by Sarah Gilbert. It is in Phase III trials. It uses live genetically engineered chimpanzee adenovirus as the delivery system for SARS-COV-2 spike proteins. Far out.
EDIT 2: I have added a link to a Youtube interview of Sarah Gilbert on June 17th. The interview is elucidating and inspires a great deal of confidence in Gilbert. She makes it sound like they are painting by the numbers and it is not a matter of if they will succeed, but only a matter of when they will be ready to deploy it on a large scale. In case the Youtube link does not post here, one can search on Youtube for “MKNavonhXyk”
Thanks for posting…excellent excellent video. Answers a lot of questions I have.
You wont see any vaccine going into my body.
Indeed, the needles are not see through
It all depends on the alternative.
If you grow up watching kids left and right suffer and die from contracting polio, you’re unlikely to refuse having your own kids vaccinated.
So far, the risks from not being vaccinated against covid, doesn’t seem quite as high. But that could change if it becomes endemic.
If Powell and Mnunchin tipped the unemployed the night before every virus stock rumor was floated they could make more money in their Robinhood accounts then they would on unemployment or working. A perpetual motion wealth creation machine, as it seems to work every time. Pretty good for the Pharma C-Suiters, too!
Lots of questions…recent data seemingly shows second infections occurring in 3 months and worse than the first. Some sort of enhancement going on with the body’s viral defenses? Recent data also shows antibodies fading quickly, in a few months at best. Having survived a moderate case of covid with mild after affects in no hurry to take the vaccine until proven out for a couple years on a few hundred million people.
Well, since SARS-CoV-2 is a coronavirus like the common flu (and let’s not mention it’s probably a chimeric virus), naturally a ‘flu shot’ vaccine is likely to ‘work’ in the same way ordinary flu shots work: they cut down on transmission of the disease in a significant percentage of the population (not all, but a good number) until such time the virus mutates and you need another vaccine. If enough people take this flu vaccine, then R0 drops below 1.0 and at least for a season or two, the disease “goes away” (until it reappears). So this is ‘good news’ no matter how you characterize it.
The common influenza virus is not a coronavirus. However, the main gist of your post regrading reducing transmission is correct.
hope!
I believe it’s called ho-pium now. They tried it in the 00’s and all the kids got addicted to it.
“In the highest-dose group, three patients had severe reactions such as fever, chills, headache or nausea. One of these had a fever of 103.28 Fahrenheit (39.6 C).” A vaccine with a high rate of reactions like this will not be well accepted.
All of the test subjects were health and younger. A high reactivity rate is not going to go well in a too large percentage of people.
I ask my wife a simple question today.
Would she rather take a brand new vaccine or take her chance with covid?
Covid it is.
I don’t buy the first model year of a car. Why would I buy the first model year of a vaccine?
Jail time? Or financial incentives to take it? Two that come to mind. I would take the vaccine if it’s relatively safe (keep in mind no vaccine is 100% safe). Same for my kids.
I don’t know how they could force people to take it, at least under the Trump administration.
As for safety, safe today and safe 2 or 10:years from now are two different things. We don’t even understand how these vaccines interact with the body. We have the ingredients and a receipt but we don’t understand what is actually happening.
Vaccines are one of the great technological advances of the 20th century but there was quite a bit of teething to get them safe and effective. I don’t expect this to be different.
They were testing minimum effective doses. I believe the smaller dose was found to be sufficiently effective and that is what the next phase of testing will use.
From the gumpf the company posted it seems there were 25 in the trial. 3 became unwell and one of those got a brain cooking fever. Compared to a .5% chance of dying for the disease not a great selling point so far.
Two things to watch.
Remember the money is in the treatment not a cure.
I feel between the ebola vac and this one. May lead to the industry to pushing congress to cut safety trials( ie cost) on future medicines. .
Does anyone else view this as a case of “counting chickens before they are hatched?” This is Phase I trials. They established a dosage and got an immune response. Does that immune response prevent people from becoming sick and prevent them from becoming carriers that spread virus and will Moderna’s vaccine candidate make it to a final product? Nobody knows.
Phase II: “Phase II trials further assess safety as well as if a drug works…”
Phase III: “Phase III trials compare a new drug to the standard-of-care drug. These trials assess the side effects of each drug and which drug works better…”
Lots of COVID-19 vaccines in the pipeline. None have been proven to prevent disease yet. Moderna up 35% in two days as though it is all a done deal that will be signed and delivered in the next 30 days. Crazy.
Phase III is really phase I.
It’s like just arriving at work. You got ready and didn’t die on the ride but you haven’t gotten anything done. Phase III is starting work.
Moderna’s latest vaccine results are promising—but it’s still too early link to technologyreview.com