Two Shots Or One? Israeli Study Shows Single Dose of Pfizer Vaccine Is 85% Effective

Mish

A study in Israel suggests it might be better to give more people one Covid shot than give two shots to one person with a delay in between.

75% to 94% Effective in Studies

Israel leads the word in the percentage of vaccinations administered so an Israeli Vaccination Study has a lot of scientific weight.

A single shot of the Covid-19 vaccine developed by Pfizer Inc. and BioNTech SE is 85% effective in preventing symptomatic disease 15 to 28 days after being administered, an Israeli study found—news that could help guide policy makers setting vaccine priorities world-wide.

The Israeli study, conducted by the government-owned Sheba Medical Center and released Friday, also found a 75% reduction in all Covid-19 infections, symptomatic or asymptomatic, after the first shot. The peer-reviewed study was published in the British medical journal Lancet as a correspondence, meaning it represents the views of the authors and not the journal.

A table published in an online annex to the Sheba study showed 94% effectiveness in preventing symptomatic Covid-19, 22 to 28 days after the first shot. This result was similar to those from two previous analyses of the Pfizer vaccine that used clinical data submitted to the U.S. Food and Drug Administration.

Canadian researchers published a letter this week in the New England Journal of Medicine saying their analysis of the data submitted to the FDA found the vaccine was 92.6% effective two weeks after the first shot. 

Israel is the Global Vaccination Leader

Israel leads the world in percentage of population vaccinated. Since it began its program Dec. 20, the country has administered the first shot to about 45% of its roughly nine million people and two shots about 30%, according the health ministry.

Israel aims to inoculate most of its population by March, a goal made possible after it paid a premium for early shipments from Pfizer and agreed to share data about its vaccine—from effectiveness to side effects.

For counties short on vaccine doses and for Covid-weary citizens this study is very welcome news.

Mish

Comments (32)
No. 1-12
PostCambrian
PostCambrian

John Hussman, the economist (and also a researcher in biosciences with published papers), has long advocated (along with others) that everyone (except for the very frail and elderly) get a single shot now in order to spread the benefit and then receive a second shot later when they are more available. This would spread the benefit much faster. The only reason that more haven't advocated this approach is that it hasn't been tested but looking at the original vaccine trial data very few people were infected after the tenth day after the first shot. It is highly unlikely that the effect of the vaccine wears off immediately after 28 days.

njbr
njbr

Just like climate science, health science evolves and changes with better knowledge, research--and trial and error.

It's how the world should work.

davebarnes2
davebarnes2

"Israeli Study Shows"
Our federal bureaucracy is way too entrenched in cautious behavior to change guidelines now.
If even one "extra" person died because of a single-shot approach, the news headlines would be devastating. There is no reward for risk taking. None.

RonJ
RonJ

Dr. Marty Makary of Johns Hopkins: "There is reason to think the country is racing toward an extremely low level of infection.

As more people have been infected, most of whom have mild or no symptoms, there are fewer Americans left to be infected.

At the current trajectory, I expect Covid will be mostly gone by April, allowing Americans to resume normal life."

"...the consistent and rapid decline in daily cases since Jan. 8 can be explained only by natural immunity. Behavior didn’t suddenly improve over the holidays; Americans traveled more over Christmas than they had since March. Vaccines also don’t explain the steep decline in January. Vaccination rates were low.."

"Some medical experts privately agreed with my prediction that there may be very little Covid-19 by April but suggested that I not to talk publicly about herd immunity because people might become complacent and fail to take precautions or might decline the vaccine. But scientists shouldn’t try to manipulate the public by hiding the truth. As we encourage everyone to get a vaccine, we also need to reopen schools and society to limit the damage of closures and prolonged isolation. Contingency planning for an open economy by April can deliver hope to those in despair and to those who have made large personal sacrifices."

With limitations, Florida has been open since last summer. It was recently noted that Florida and California had a similar trajectory in cases during the winter surge, despite the different approaches between the two.

Doug78
Doug78

It is good news but in France from a political point of view going to one shot would be attacked because first of all we don't have much of the vaccine to begin with and secondly the medical aspects of this epidemic has been discussed so much that generally now people don't know who to believe. Media here chooses who gets on mainly on their entertainment value. A boring but correct specialist by Darwinian media evolution is eliminated from the pool by the one who can create more controversy and more buzz. It's a general problem for scientists for some time now that journalists twist their work and words into a story that gets internet hits but that also misinterprets the original meanings.

Sechel
Sechel

It's interesting how Israel got to the unique position of leading the world in vaccinations. First it has a national medical system so its easy to organize vaccinations. Second with only 8 million citizens, rouhghly the same as Switzerland it was able to cut a deal with Pfizer and get vaccines for the entire country in exchange for providing real time data to Pfizer . In essence Israel became a laboratory for pfizer. It's an intereting turn-around after bungling its earlier response where it took its foot off the gas too soon after some initial success and the infection rate spiked.

Johnson1
Johnson1

Stock market and crypto wealth generation are on full throttle. I know some twenty somethings and even teenagers that are going out and buying new cars and even loaning their parents money.

They have no fear and are not buy and hold investors. They move to a hot stock, buy, sell, and book the profits. Amazing.

I know a neighboor kid how took his 9k from lawn mowing and is playing the market. He is up over $30k. He took out his original 9k investment so he will not lose his initial investment and is playing with house money.

Now he just buys and sells stocks each week and pulls out at least $500 a week for spending money.

Sechel
Sechel

@Mish, i'd suggest including Fauci's comments on this. how He points out that the people in the study were on the younger and healthier side. Further more researchers couldn't say how long a single vaccine shot would last . Fauci is also worried that a single shot would have less effect on the more powerful strains.

The Israeli study is interesting but I can understand U.S. health professionals not to want to change course after one study

Sechel
Sechel

He pointed out that the people in the study were on the younger and healthier side and the researchers could not say how long the protection from one shot of the vaccine would last. He also said it was possible that a less-than-optimal dose might not kill the most powerful variants of the virus, theoretically allowing them to spread more quickly in the population.

“We want the public not to be confused. The recommendation from the F.D.A. is two doses, just as it always has been,” Andy Slavitt, a White House virus adviser, said during the briefing.

Realist
Realist

Lots of good vaccine news. Which should really help the world economy recover a bit. However, I still suspect Covid will be endemic. No time to let our guard down. Continue with masks, distancing, etc for as long as you can possibly stand it. I prefer to avoid the one step forward, two steps back scenario.

Eddie_T
Eddie_T

Since we just had a week of what amounts to lockdown...and new infections were already dropping like a rock...I expect more good news here...but the dashboards haven’t been updated in more than a week, so I don’t know.

Vaccinations were disrupted by the weather events....and supply is still short. We are up to 4.4 million vaccinated statewide, about 6.4% of the population. I guess that isn’t bad, considering twenty percent of the public are afraid of the vaccine.

Hilayu77
Hilayu77

Online therapy is also a good way to support your health from different problems. As for me, I am currently following https://calmerry.com/ which is helping me to find the right solution in 2021. We all are struggling from mental disorders and it is really important to follow different solutions in order to feel better. I can say that sometimes I am using online therapy that helps me to overcome some problems that are eating me from inside.


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