Two Shots Or One? Israeli Study Shows Single Dose of Pfizer Vaccine Is 85% Effective

75% to 94% Effective in Studies

Israel leads the word in the percentage of vaccinations administered so an Israeli Vaccination Study has a lot of scientific weight.

A single shot of the Covid-19 vaccine developed by Pfizer Inc. and BioNTech SE is 85% effective in preventing symptomatic disease 15 to 28 days after being administered, an Israeli study found—news that could help guide policy makers setting vaccine priorities world-wide.

The Israeli study, conducted by the government-owned Sheba Medical Center and released Friday, also found a 75% reduction in all Covid-19 infections, symptomatic or asymptomatic, after the first shot. The peer-reviewed study was published in the British medical journal Lancet as a correspondence, meaning it represents the views of the authors and not the journal.

A table published in an online annex to the Sheba study showed 94% effectiveness in preventing symptomatic Covid-19, 22 to 28 days after the first shot. This result was similar to those from two previous analyses of the Pfizer vaccine that used clinical data submitted to the U.S. Food and Drug Administration.

Canadian researchers published a letter this week in the New England Journal of Medicine saying their analysis of the data submitted to the FDA found the vaccine was 92.6% effective two weeks after the first shot. 

Israel is the Global Vaccination Leader

Israel leads the world in percentage of population vaccinated. Since it began its program Dec. 20, the country has administered the first shot to about 45% of its roughly nine million people and two shots about 30%, according the health ministry.

Israel aims to inoculate most of its population by March, a goal made possible after it paid a premium for early shipments from Pfizer and agreed to share data about its vaccine—from effectiveness to side effects.

For counties short on vaccine doses and for Covid-weary citizens this study is very welcome news.

Mish

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Hilayu77
Hilayu77
3 years ago

Online therapy is also a good way to support your health from different problems. As for me, I am currently following link to calmerry.com which is helping me to find the right solution in 2021. We all are struggling from mental disorders and it is really important to follow different solutions in order to feel better. I can say that sometimes I am using online therapy that helps me to overcome some problems that are eating me from inside.

Eddie_T
Eddie_T
3 years ago

Since we just had a week of what amounts to lockdown…and new infections were already dropping like a rock…I expect more good news here…but the dashboards haven’t been updated in more than a week, so I don’t know.

Vaccinations were disrupted by the weather events….and supply is still short. We are up to 4.4 million vaccinated statewide, about 6.4% of the population. I guess that isn’t bad, considering twenty percent of the public are afraid of the vaccine.

Sechel
Sechel
3 years ago

He pointed out that the people in the study were on the younger and healthier side and the researchers could not say how long the protection from one shot of the vaccine would last. He also said it was possible that a less-than-optimal dose might not kill the most powerful variants of the virus, theoretically allowing them to spread more quickly in the population.

“We want the public not to be confused. The recommendation from the F.D.A. is two doses, just as it always has been,” Andy Slavitt, a White House virus adviser, said during the briefing.

Sechel
Sechel
3 years ago
Reply to  Sechel

He=Fauci

Sechel
Sechel
3 years ago

@Mish, i’d suggest including Fauci’s comments on this. how He points out that the people in the study were on the younger and healthier side. Further more researchers couldn’t say how long a single vaccine shot would last . Fauci is also worried that a single shot would have less effect on the more powerful strains.

The Israeli study is interesting but I can understand U.S. health professionals not to want to change course after one study

Johnson1
Johnson1
3 years ago

Stock market and crypto wealth generation are on full throttle. I know some twenty somethings and even teenagers that are going out and buying new cars and even loaning their parents money.

They have no fear and are not buy and hold investors. They move to a hot stock, buy, sell, and book the profits. Amazing.

I know a neighboor kid how took his 9k from lawn mowing and is playing the market. He is up over $30k. He took out his original 9k investment so he will not lose his initial investment and is playing with house money.

Now he just buys and sells stocks each week and pulls out at least $500 a week for spending money.

Johnson1
Johnson1
3 years ago
Reply to  Johnson1

I am also amazed how COVID has helped so many stock achieve all time highs. Vail Resorts (MTN) is at an ATH even though ski traffic is down this year. The stock is actually 16% above pre-covid with fewer skiers and less revenue. If we did not have COVID…the stock would be much lower in my opinion. Same with Hilton, occupancy is down 30% yet stock is ATH. Hilton said said occupancy will not be normal until 2022.

Felix_Mish
Felix_Mish
3 years ago
Reply to  Johnson1

Unmistakable market top signal.

Sechel
Sechel
3 years ago

It’s interesting how Israel got to the unique position of leading the world in vaccinations. First it has a national medical system so its easy to organize vaccinations. Second with only 8 million citizens, rouhghly the same as Switzerland it was able to cut a deal with Pfizer and get vaccines for the entire country in exchange for providing real time data to Pfizer . In essence Israel became a laboratory for pfizer. It’s an intereting turn-around after bungling its earlier response where it took its foot off the gas too soon after some initial success and the infection rate spiked.

Doug78
Doug78
3 years ago
Reply to  Sechel

It was risky but it offered something very valuable to Pfizer. Real-time data for a new vaccine on 8 million people gives them an unparalleled data-set not only on this vaccine’s properties but also a leg-up on research on competitors. They offered a deal that Pfizer couldn’t resist in exchange of enough vaccine to inoculate their total population in a very short time. Try and put a dollar value on that.

Sechel
Sechel
3 years ago
Reply to  Doug78

i think it was low risk. The data on the trial studies was very good and while the vaccine was new it was built on messener RNA technology which had already been developed. And then you have the risk that you know people will die if you don’t vaccinate.

Doug78
Doug78
3 years ago
Reply to  Sechel

They made the correct decision. When I said it was risky I meant that the side effects could have been much worse than it turned out to be. That’s a risk with a population which has less genetic diversity.

Doug78
Doug78
3 years ago
Reply to  Sechel

There was risk in the sense that Israel has a less diverse genetic pool than the original trial and that could have generated unexpected sever-side effects. RNA technology had already been used before but nothing near the quantity used for the vaccine. It seems not risky because it worked. The decision to do so was not as easy as it seems.

Doug78
Doug78
3 years ago

It is good news but in France from a political point of view going to one shot would be attacked because first of all we don’t have much of the vaccine to begin with and secondly the medical aspects of this epidemic has been discussed so much that generally now people don’t know who to believe. Media here chooses who gets on mainly on their entertainment value. A boring but correct specialist by Darwinian media evolution is eliminated from the pool by the one who can create more controversy and more buzz. It’s a general problem for scientists for some time now that journalists twist their work and words into a story that gets internet hits but that also misinterprets the original meanings.

RonJ
RonJ
3 years ago

Dr. Marty Makary of Johns Hopkins: “There is reason to think the country is racing toward an extremely low level of infection.

As more people have been infected, most of whom have mild or no symptoms, there are fewer Americans left to be infected.

At the current trajectory, I expect Covid will be mostly gone by April, allowing Americans to resume normal life."

“…the consistent and rapid decline in daily cases since Jan. 8 can be explained only by natural immunity. Behavior didn’t suddenly improve over the holidays; Americans traveled more over Christmas than they had since March. Vaccines also don’t explain the steep decline in January. Vaccination rates were low..”

“Some medical experts privately agreed with my prediction that there may be very little Covid-19 by April but suggested that I not to talk publicly about herd immunity because people might become complacent and fail to take precautions or might decline the vaccine. But scientists shouldn’t try to manipulate the public by hiding the truth. As we encourage everyone to get a vaccine, we also need to reopen schools and society to limit the damage of closures and prolonged isolation. Contingency planning for an open economy by April can deliver hope to those in despair and to those who have made large personal sacrifices.”

With limitations, Florida has been open since last summer. It was recently noted that Florida and California had a similar trajectory in cases during the winter surge, despite the different approaches between the two.

Rbm
Rbm
3 years ago
Reply to  RonJ

Different approaches at state level do not make a difference when individuals act the same.

randocalrissian
randocalrissian
3 years ago
Reply to  RonJ

Makary doesn’t seem to have an agenda here. He does rely on some extrapolation that makes this more theory than anything, but there is enough circumstantial evidence supporting his idea that it is worth lending some credence to the possibility. But hopefully nobody reads his words and is foolish enough to loosen their policies right now.

JoeJohnson
JoeJohnson
3 years ago
Reply to  RonJ

Florida has been open for some time now. A lot of our elderly are getting vaccinated. I’m a health care worker so I decided to get the shot too. Luckily I had absolutely no negative reactions.

davebarnes2
davebarnes2
3 years ago

“Israeli Study Shows”
Our federal bureaucracy is way too entrenched in cautious behavior to change guidelines now.
If even one “extra” person died because of a single-shot approach, the news headlines would be devastating. There is no reward for risk taking. None.

njbr
njbr
3 years ago

Just like climate science, health science evolves and changes with better knowledge, research–and trial and error.

It’s how the world should work.

SyTuck
SyTuck
3 years ago
Reply to  njbr

But wasn’t it 10 years ago that 95% of scientists agreed that they were 95% certain of Climate change?

That doesn’t leave much room for evolution and change.

njbr
njbr
3 years ago
Reply to  SyTuck

Yes, there is agreement that there is climate change, the issue is when and what will the critical effects be.

When’s the last time any of us have sat through climate change forced by a very sudden spike in CO2 and its equivalents in the atmosphere?

Never.

Predicting the future is hard. There is no roadmap saying exactly what 2030, 2040 or 2050 or 2100 will be like.

But we all know that unbreaking an egg is damn difficult.

So

Doug78
Doug78
3 years ago
Reply to  njbr

We broke the egg when we decided to become farmers and herders.

Doug78
Doug78
3 years ago
Reply to  njbr

Which came about because of climate change.

njbr
njbr
3 years ago
Reply to  Doug78

You might then realize that there are climates that have been hospitable to humans and climates inhospitable to humans in the history of the world

Because of the size and interdependnce of the worlds populations and economies, the blythe assumption of “it’ll all be fine” is pretty foolish.

Doug78
Doug78
3 years ago
Reply to  njbr

Who said we all will be fine? I said that the Human race will adapt pretty well. Being fine depends on your own individual circumstances and that depends less on climate change and more to your access to capital, medicine, networks and that great unknown Lady Luck. People live in all climates on Earth and have been doing so for thousands of years. Next to the cockroach we are the most adaptable species on Earth.

PostCambrian
PostCambrian
3 years ago

John Hussman, the economist (and also a researcher in biosciences with published papers), has long advocated (along with others) that everyone (except for the very frail and elderly) get a single shot now in order to spread the benefit and then receive a second shot later when they are more available. This would spread the benefit much faster. The only reason that more haven’t advocated this approach is that it hasn’t been tested but looking at the original vaccine trial data very few people were infected after the tenth day after the first shot. It is highly unlikely that the effect of the vaccine wears off immediately after 28 days.

davidyjack
davidyjack
3 years ago
Reply to  PostCambrian

“The only reason that more haven’t advocated this approach is that it hasn’t been tested but looking at the original vaccine trial data very few people were infected after the tenth day after the first shot. It is highly unlikely that the effect of the vaccine wears off immediately after 28 days”

But perhaps much of it wears off after 2 or 3 months.

davidyjack
davidyjack
3 years ago
Reply to  PostCambrian

“The only reason that more haven’t advocated this approach is that it hasn’t been tested but looking at the original vaccine trial data very few people were infected after the tenth day after the first shot. It is highly unlikely that the effect of the vaccine wears off immediately after 28 days”

But what about after 2 or 3 months?

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